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Exosomes

Exosomes at Performance Health

What are Exosomes?
Exosomes are tiny, naturally occurring extracellular vesicles released by cells that act as messengers, carrying proteins, growth factors, and signaling molecules that influence how neighboring cells repair and regenerate. They play a central role in cellular communication, tissue healing, and collagen remodeling.

 

What brand do you use?

We use AnteAge stem cells because of their proven track record of safety and transparency. Their primary laboratory where their   products are made is located in California, USA, which has notoriously strict requirements. The exosomes used in AnteAge products are stem cell derived and sourced from bone marrow and placental tissue from thoroughly vetted United States donors. Biosomes, by contrast, are manufactured exosome analogs. They do not contain genetic material, but instead are engineered liposomal carriers designed to mimic the signaling function of natural exosomes. By encapsulating regenerative peptides and active molecules, Biosomes ensure stability and efficient delivery into the skin or scalp. While exosomes provide biologic “instructions” for repair, biosomes provide a safe, bio-engineered way to enhance penetration and regenerative outcomes without any cellular components.

 

How are exosomes used?

Exosomes are FDA cleared for topical use only. Many providers, including providers at Performance Health, will use exosomes during the microneedling process – with explicit permission from the patient to use them in this off -abel manner. Some patients request to be injected with exosomes, which we will perform at Performance Health by request only. We feel that this is too high risk of an off-label use to openly market.

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​How do exosomes help your skin?

When combined with microneedling, the micro-channels allow these products to penetrate into the deeper layers of the skin, amplifying rejuvenation effects. This pairing inn theory enhances collagen remodeling, reduces redness more quickly, and accelerates visible improvements in skin tone, elasticity, and radiance. Patients often notice faster recovery and more pronounced results compared to microneedling alone.

 

Risks of exosomes:

The primary category of risks associated with exosomes are the risks that are inherent to microneedling and injection – infection, skin reactions, unsatisfactory results etc. The secondary category are the risks that are largely unknown because we do not have robust clinical data on the long-term safety, efficacy and effects of exosomes. The risks are likely to be low, but we do not know what we do not know.

Receipts (Research)

Acne Scars

Kwon, H. H., Yang, S. H., Lee, J., Park, B. C., Park, K. Y., Jung, J. Y., Bae, Y., & Park, G. H. (2020). Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta dermato-venereologica, 100(18), adv00310. https://doi.org/10.2340/00015555-3666

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Facial Aging

Kim, J., Kim, H., Lee, Y., Kim, J., & Kim, M. (2023). Topical application of adipose-derived stem cell exosomes after microneedling improves signs of skin aging: A randomized split-face study. Journal of Cosmetic Dermatology, 22(6), 1643–1651. https://doi.org/10.1111/jocd.15121 https://scholarworks.bwise.kr/cau/bitstream/2019.sw.cau/71681/1/Efficacy%20of%20combined%20treatment%20with%20human%20adipose%20tissue%20stem%20cell-derived%20exosome-containing%20solution%20and%20microneedling%20for%20facial%20skin%20aging%20A%2012-week%20prospective%2C%20randomized%2C%20split-face%20study.pdf

 

Skin Brightening

Cho, B. S., Lee, J., Won, Y., Duncan, D. I., Jin, R. C., Lee, J., Kwon, H. H., Park, G.-H., Yang, S. H., Park, B. C., Park, K. Y., Youn, J., Chae, J., Jung, M., & Yi, Y. W. (2020). Skin Brightening Efficacy of Exosomes Derived from Human Adipose Tissue-Derived Stem/Stromal Cells: A Prospective, Split-Face, Randomized Placebo-Controlled Study. Cosmetics, 7(4), 90. https://doi.org/10.3390/cosmetics7040090

 

Melasma

Budamakuntla, L., Loganathan, E., Suresh, D. H., Shanmugam, S., Suryanarayan, S., Dongare, A., Venkataramiah, L. D., & Prabhu, N. (2013). A randomised, open-label, comparative study of tranexamic acid microinjections and tranexamic acid with microneedling in patients with melasma. Journal of Cutaneous and Aesthetic Surgery, 6(3), 139–143. https://doi.org/10.4103/0974-2077.118405

PubMed: https://pubmed.ncbi.nlm.nih.gov/24163529/ ; PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3800287/ 

 

Atrophic Scars
Sitohang, I. B. S., Sirait, S. A. P., & Suryanegara, J. (2021). Microneedling in the treatment of atrophic scars: A systematic review of randomised controlled trials. International Wound Journal, 18(5), 577–585. https://doi.org/10.1111/iwj.13559
PubMed: https://pubmed.ncbi.nlm.nih.gov/33538106

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Facial Rejuvention with Stem Cells

Liang, X., Li, J., Yan, Y., Xu, Y., Wang, X., Wu, H., Liu, Y., Li, L., & Zhuo, F. (2022). Efficacy of microneedling combined with local application of human umbilical cord‑derived mesenchymal stem cells conditioned media in skin brightness and rejuvenation: A randomized controlled split‑face study. Frontiers in Medicine, 9, Article 837332. https://doi.org/10.3389/fmed.2022.837332

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Microneedling as Adjuvant Treatment for Melasma
Bailey, A. J. M., et al. (2022). Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta‑analysis. Journal of the American Academy of Dermatology, 86(4), 797–810. https://doi.org/10.1016/j.jaad.2021.03.116

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Microneedling Plus Exosomes for Melasma
Proietti, I., Battilotti, C., Svara, F., Innocenzi, C., Spagnoli, A., & Potenza, C. (2024). Efficacy and tolerability of a microneedling device plus exosomes for treating melasma. Applied Sciences, 14(16), Article 7252. https://doi.org/10.3390/app14167252

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